TMAU2 is a yeast infection of genital organ at the pelvic re

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TMAU2 is a yeast infection of genital organ at the pelvic re

Postby jasmine711 » Sat May 14, 2016 9:27 pm

This is the article I wrote based on the RareConnect TMAU forum information, so when I mention "forum" I actually mean the RareConnect.

I am so glad for that I have found this forum. It's been a lonely journey. There hasn't been anyone who would talk to me upon this illness. The stories and comments here are really encouraging. With a background of biological sciences, I have been observing and investigating this thing myself. I would like to share all my findings on symptoms and causes, and wish to have some opinions, discussions, and feedback. I wish what I have shared could be helpful.

This article is very long and here are the highlights –
1. TMAU2 is a yeast infection of genital organ at the pelvic region, and is very likely to be the consequence of “leaky gut“.
2. Yeasts use choline as nutrition source and break them down to TMA
3. There were cases in which anti-fungal medicine can treat TMAU/body odour
4. Below I have explained all these in detail and provided with diet and supplement suggestions.


Gastrointestinal symptoms

Symptoms occurred in April/May 2013. It was the time when I have returned to Asia after 10 years of life in Europe (14-24 years old). The poor food hygiene (of the family I lived with during that time) and the humid, hot weather (35ºC everyday) struck me down. Gastrointestinal symptoms appeared first - continuous small amount of gas after meal, chronic diarrhoea, lower abdominal pain, and then one day the odour appeared. Other symptoms followed the odour including fatigue, irregular heartbeat, short of breath, body heat (feeling like a fever), even insomnia.

From these symptoms I was able to tell that it was some kind of infection. Especially when the odour exaggerated so much after a night of insomnia, I knew there was some kind of opportunistic microorganism invading my body. As well that, according to my lab experiences, only microorganisms make this terrible smell (they always do). At the beginning I thought it was some kind of bacterial infection at the lower abdomen, but doctors said bacteria would cause more severe effects such as necrosis. To them, my health just seemed to be alright. Despite of no evidence of infection, I was put on antibiotics for a short period (2-3 weeks) upon my request, but that didn't solve my problems. Those gastroenterologists thought it was just irritable bowel syndrome caused by mental stress, but I knew it was the imbalance of gut bioflora caused by the contaminated food, but they have no knowledge upon it when I mentioned it to them.

Finally one day I found this thing called "leaky gut" - alteration of intestine permeability as a result of intestine inflammation, biofloral alteration, and yeast overgrowth. It described all the gastrointestinal symptoms I had and very importantly, it states this illness is correlated with the overgrowth of yeast while the gut flora was damaged. It was since then I knew what I have been fighting was not bacteria, but actually YEASTS

Genital infection

Following those systemic symptoms, I started to notice that "vaginal infections" occurred much more often than before, as well as urinary track infections which I experienced only once or twice before. Actually I didn't really feel pain or itching at the outer genital part, but had vaginal discharge all the time. I had been to gynaecologist several times but every time I got the same answer - there was no sign of infection or inflammation on the surface of vaginal track or the inner lining of uterus, the result of ultrasound imaging looked fine too. I was told that it might just because of weak immune functions due fatigue and stress. I have already quit my job at that time and I insisted that I had absolutely regular life style with plenty of rest. After several visits, the doctor suggested me to do some immune function checks, and again the results turned out normal (I have done immune blood test 2 times and had excess eosinophil and basophil respectively in each test but they say it’s fine. I also had excess IgE expression that they said it was allergy which every body has).

Although I couldn't get any more answers here but I started to realise that this infection must be internal. I felt it was something deep inside of the genital organs, probably ovaries I would say, since there's no symptoms neither sign of infections from the outer part. Sometimes I can feel discharge passing through the vagina, causing an irritating, stingy feeling.

The real cause of odour - Yeast Pelvic infection (internal genital organ infection)

During these years of search, I have come across a few cases linking genital yeast infection and malodour/bad breath. The first case was an article written by a health specialist (not a doctor). The author wrote that she had encountered a woman with severe body odour and realised that is was SEVERE FUNGUS PELVIC INFECTION (of the genital organ). After treatments, the odour disappeared. The second case was written by a nutritionist/doctor who treats patients with diet plans and supplements. He had a woman patient with "horrible bad breath" which the husband described as the smell of trash. Again, this patient suffered from continuous VAGINAL FUNGUS INFECTION. She was put on low-sugar diet plus supplements and the bad breath was relieved along with the infection. In fact, I have also read some more articles mentioning the link between bad breath and vaginal fungus infections, but the case above was the only one that has written about the outcomes of treatment. Just now I have read that the TMAU symptom of a guy was cured with ANTI-FUNGAL TREATMENT.


Yeasts are single-cell organisms belong to the fungus kingdom. They are natural inhabitants in our gut. Unlike moulds, yeasts do not form hyphae, which is the furry structure you see on mouldy food. Doctors here seem not to make distinctions and simply collectively call "fungus infections". In the US, yeast infection is very often referred as "candida infection", since candida is the most common infectious yeast strain found in human. Yeast infections are a rather vague area in the mainstream medication and are difficult to diagnose. There are several general misunderstood concepts of yeast infections -

*Yeast infections mainly take place on the surface of human body, for example, skin and outer genital (wrong)
The main site of yeast growth is gut, where they naturally live. In a healthy person, the "good bacteria" in gut biodome maintain a balance and suppress the growth of yeast. When the balance is broken by contaminated food, antibiotics, stress, or lack of sufficient blood supply, it would allow the opportunistic yeasts to prosper and even spread out. Sugar in diets is an important contribution factor to yeast overgrowth and infections including vaginal infections, but I don't know whether it acts directly on gut or through blood sugar level.

*Systemic yeast infection (yeasts in blood) can only happen on critically ill patients (wrong)
Unlike bacteria, yeasts seem to be able to disguise and not to trigger much immune response. They can even break a white blood cell after being engulfed. When bacteria reproduce in blood, it causes a life-threatening symptom called sepsis. Most doctors regard yeasts behaviour in the way as bacteria and expect them to trigger the same responses. The truth is, yeasts can stay in blood quietly without showing obvious symptoms. When people aged, they could even enter the red blood cells and it's a sign of senescence. There's simple yet powerful diagnostic tool which you can see yeasts in blood, called Live Blood Analysis. What it does is simply magnify a drop of blood under a microscope in high resolution and see what's in it.

Yeasts behave like a transparent opportunistic pathogen and are difficult to diagnose with the mainstream medication. They slowly rot our body without our awareness. This is what I have been struggling for - doctors here don't believe there's such a thing and refuse to make examinations neither prescribe anti-fungal medicines.

Finally, what's the link between yeasts and TMAU? The odour of TMAU comes from trimethylamine (TMA) accumulating in blood. As secondary TMAU (TMAU2) patients have normal functioning FMO3, instead of having problem at breaking TMA down, the reason for TMA accumulation might be that there is too much of TMA being produced. What I found between yeast and TMA is that, YEASTS ACTUALLY USE CHOLINE/TMA-O AS NUTRIENT SOURCE BY BREAKING THEM DOWN INTO TMA. I have read in scientific papers described that in lab they use choline/TMA-O (as nitrogen source) for growing yeasts cultures. What I think is, YEASTS ARE ACTUALLY THE SOURCE OF TMA PRODUCED IN OUR BODY, and giving the terrible smell. On wikipedia it describes TMA as the product of DECOMPOSITION and is the source of the rotten smell. I think decomposition is exactly what yeasts do.

There are some other observations showed that the pattern of the odour could be related to infections. A mother of a TMAU child said, the odour doesn't always follow their diet. Some times having choline is fine, and some other times aren’t. It indicated that THERE'S AN INTERMEDIATE FACTOR INFLUENCING THE AMOUNT OF CHOLIN BEING TURNED INTO TMA, and which this factor is variable. In my own case, an allnighter/lack of sleep would push the odour to a peak and takes several days to return back down even I have rested extremely well on the next day of the allnighter. I think this factor doesn't really go along with metabolism. Lacking sleep is known to exaggerate yeast infections. I would say it's the level of yeast population in the body, as a primary factor, decides the intensity of the odour. They flourish at an opportunity and takes time to have their number reduced back down, which explains the lag. I have also noticed that many of you here are from countries with warmer weather. Yeast infections are more common in areas with hot and humid weather.


Here comes the question - why doesn't every one with leaky gut (yeast overgrowth) develop odour? My odour also came a while AFTER the gastrointestinal symptoms. My speculation is - the odour appears when the population of yeast is high enough, and the huge rise of yeast population happens when the yeasts "migrates" from gut to genital organs and causes infections there.

Two cases I mentioned above indicated that there's a link between GENITAL FUNGUS INFECTION And BAD BREATH/ODOUR. I have them all after the onset of this illness. I have also noticed that the majority of you here are women, mentioning about puberty, female hormones changes, menstrual cycles, ovarian cysts, and etc. It seems that TMAU is closely correlated with female reproductive functions and genital organs. However, I'm not the only one here who had been to a gynaecologist and had no infection spotted, although I still have vaginal discharge all the time.

When these gynaecologists are diagnosing infections, they only examine from the outer part, but the internal organs such as ovaries at the pelvic region are difficult to reach. Plus I am not a sexually active person. The possibility of infection from outside is low. I have the thought that the cause of infection must be internal. I have mentioned about leaky gut and it's link with yeast overgrowth. With addition that scientific papers states that GUT IS IN FACT THE PRIMARY SITE FOR YEAST INFECTION, I think there's a link between gut infections and pelvic genital infections due to their proximity. Gut and genital organs both sit in the pelvic region sticking to each other. If female probiotics works by intake orally and then migrate from gut to genital organs, there's huge possibility that pathogenic microorganisms like yeasts can do the same.

My assumption is that, YEAST OVERGROWTH IN GUT DUE TO GUT FLORA IMBALANCE, CAN IN FACT LEAD TO GENITAL ORGAN INFECTION AT THE PELVIC REGION, ESPECIALLY WHEN THE PERMEABILITY IS INCREASED (AS KNOWN AS "LEAKY GUT"), and therefore showing no signs of outer infections. I think it is what TMAU2 is all about. There are many of you mentioned that TMAU appeared after taking antibiotics. Antibiotics are known to cause severe damage to the gut flora, which takes at least months to restore. Isn't it the best chance for yeast to take over and prosper in your body and spread to the genital organ? In addition, taking l-glutamine, which is an amino acid that repairs gut lining, have made me almost free from vaginal discharge (discharge always come within 20 minutes after having something sweet). When I'm writing up this article, my l-glutamine ran short and I was waiting for the new ones to arrive. The infection/vaginal discharges was obviously worsen during this one week of gap, indicating that gut lining does play a role in this internal genital infection.

For some additional information, I was on hormone-modulating medicine for the excess prolactin secretion when the odour occurred. My period was often delayed, with very small amount of brown, clotted blood. I have sexual hormone disorders - deficient female hormone (probably oestrogen) and excess male hormone (probably androgen) but have never been on a treatment for that. I have ovarian cysts. I think that the poor condition/function of the female reproductive system rendering the organs susceptible for infections is one important factor of why leaky gut can turn into genital infection. In addition, I have familial hyper-cholesterolaemia, which means that my liver lacks certain kind of enzymes for breaking down the cholesterol molecules. I am not sure whether it has a role in TMAU as TMA is metabolised in liver.

I know there are guys suffering from TMAU2 too but the cases seem to be less. In the male case I have encountered, lower abdominal pain, gastrointestinal problems, urinary track infections were also reported, showing that it's also something to do with pelvic infection. I think the reason why there are more women than men suffering from TMAU is because of the structural and functional differences of genital organs. Ovaries and uterus are nutrient-rich with periodic pH changes/hormone secretion changes that lower the defense and allow microorganisms to happily thrive within.

Some of the treatments discussed in the forum also correlate with pelvic region or yeast infection - antibiotic Flagyl has pelvic infection as one of its effective target regions. Zinc also works at the lower abdominal region by boosting gut function. Coconut oil is known for it’s yeast-killing effect.


I have observed some neurological symptoms following the condition of infection. When I felt the infection was exaggerated, I noticed that I would have more compulsive actions, and when my body was doing well, I feel more relaxed and sooth. It could be observed in small daily tasks like brushing teeth or taking shower. It was not like anxiety but more like I was always in a rush for something else although there actually wasn't any. There could be 2 reasons I have speculated - firstly yeasts produce neurotoxins. It could be the metabolites of yeasts affecting my nerve system. The other reason is that choline is a neurotransmitter. The level of choline in blood has a reversed correlation with degree of anxiety. It means that if yeasts depleted the choline in blood for their own nutrition, patients could be affected by this lack of choline and develop neurological symptoms. It's known that gastrointestinal impairment also causes nervous excitement and muscle tension.

Heart problem was another major symptom appeared at the later part of this disease. In May 2015 I had a heart-attack-like incident. I was getting up from bed and my heart suddenly struck by severe pain and I couldn't move, then my heartbeat became extremely fast and my hands and feet turned cold. I went to a nearby hospital and on the way I felt I was losing breath and losing conscious. Reaching the emergency room my heartbeat and pressure were both high but electrocardiogram showed no abnormality. The only thing detected was urinary tract infection with unknown microorganism (the sample was foggy they said). While sitting on chair resting, I was shivering a lot, sometimes felt sober and sometimes felt faint. MY face was red and body temperature was high like I was having some kind of fever. After about an hour later things started to calm and I felt a bit better, then I just returned home. In the next 2 days I wasn't able to stand or walk much because I easily gasped. I talked to a cousin who was a nurse and she said it sounded like a myocardial infraction, but also wondered why there was no sign on electrocardiogram. What was interesting was that this heart symptom has happened a few more times but milder, and every time before it happened, I felt kidney pain and worsen genital infection. The kidney pain before the first "heart-attack" was the worst one. I felt quite uncomfortable that I even went to see a doctor, but of course the tests turned out fine, only slightly proteinuria was shown which they claimed to be "just normal". I have also read a patient of leaky gut having the same experience. She had been on strict candida diet (low carbohydrate), but one day she went to a party and had lots of sugar/carbohydrate, after that she had the same heart-attack symptom with nothing diagnosed. What I think is, it's the yeast infection coming to the heart, as it always happens when there's an outburst of infection. It always takes a few days to recover even with a mild one. The most recent one I had was a week ago and it was with chest bone pain. It was also the time when I had a gap of taking l-glutamine, having more dessert than usual, and the exaggeration of genital infection

In the recent months I also easily felt kidney pain after eating some protein food such as egg, and had bubbled urine after having most other protein food. This pain and bubbled urine had disappeared after I started taking l-glutamine that repaired the gut lining. I think some substances leaking from gut into blood were laying a burden on kidney. I have also noticed that red yeast rice supplement also got me bad kidney pain, indicating that yeast metabolites are irritating to kidney too. In fact I feel most fermented food gives me an adverse effect. After eating certain amounts I would feel increased heart rate and fatigue. I have read some other TMAU patients reported the same.

Recently I have been diagnosed that my oestrogen level has dropped to a new low and my period has vanished for a few months already. I am not sure if it was because that I stay awake at night and sleep in the morning, or was due to the long-term vegetarian diet, or it is the yeasts that have been occupying my ovaries. In fact I have been taking some more meat for a while but seems it's not working. My case is quite severe that even when I am on vegetarian diet with no egg, dairy, and bean products, the odour is still very strong. There must be other choline sources the yeasts are taking. Our body produces some choline but I think these yeasts have been feeding on my tissue.


If TMAU is really a yeast infection at the genital organs at the pelvic region, there are 4 levels where the odour can be handled -
1. Yeast infection (primary cause) 2. Choline (source of odour) 3. Liver function (metabolism of TMA) 4. Clothing


I haven't tried any medicine for yeast infection, but as mentioned above in the case which the men's TMAU was cure, nystatin was used. However, that article was back in 2009 and I'm not sure if it's still the anti-fungal drug doctors prescribe now. This sort of anti-fungal drug neither provide you permanent cure - resistance can always rise and infection can return. It might become a long-term medication.

During these years I once moved to shanghai for a coupled of months and went to see a Chinese herbal doctor, took some herbal medicine. The odour seemed to reduce a bit over all. But It might also be due to the cold, dry weather or the hot lemon water I had everyday. But then when I have moved back to Taiwan where the weather is hot and humid, stopped taking Chinese herbal medicine, things quickly turned back down again.

Supplements & Diet

Yeasts live on sugar. It's a common sense here that consuming sugar or refined carbohydrates can lead to or exaggerate vaginal yeast infection. I always have vaginal discharge within 20 minutes after eating something sweet like cake or sweeten drink. Therefore the basis of my diet is to avoid all the refined food, sweets, and white rice (take brown rice instead). I was once on a very strict candida (yeast) diet in which was consisted of almost all protein and no carbohydrates. It quieted my gut but then came up with kidney and heart problems, so I had gone back to a more balanced diet. The key principle of my diet is to have fresh, natural food.

There was a girl who mentioned that the body odour of her mother disappeared after she has started taking diabetes medicines. The first thing came up in my mind was the cut-off of blood sugar level (which might be a big source of nutrient for yeasts).

There are some supplements I have been taking but none of them have cured me. However I still try my best to keep the activity of yeasts low.

1. L-glutamine is the supplement that I consider as the most essential one. It's an amino acid which repairs intestine lining, often used along with chemotherapy or used by patients with bowel inflammation. It reverses the increased permeability of gut lining and prevents some molecules from leaking into blood. It has improved many of my symptoms - no more kidney pain nor bubble urine, and reduced the frequency of vaginal discharge to almost none.

2. Zinc. Actually I'm not sure how it works but I know it’s greatly beneficial to gut function. It seems mainly support the function of the pelvic region. Many people in the forum also said zinc have been helpful.

3. Probiotics. It greatly improved my gastrointestinal/digestive functions. These bacteria help digestion and may potentially repress the growth of yeasts. I think it just has overall beneficial effects and is worth taking. There are female probiotics targeting the genital organs but I'm not sure how much they work. In general I would recommend to choose the probiotics with more bacteria strains (can be up to 10-15) rather than higher number of bacteria. I change brands from time to time in order to give a range of variety.

4. Hot lemon water with soda (sodium bicarbonate). Yeasts can't survive in alkaline environments. The more acidic your blood is, the more you are susceptible for yeast overgrowth. An Italian doctor who regards cancer as a chronic yeast infection suggests his patients to take one tea spoon of soda (sodium bicarbonate) in water every morning to maintain the alkalinity of digestive track and so on. Therefore I make hot lemon water with baking soda almost everyday, especially after having sweets/desserts. Lemon is alkaline food too and soda releases CO2 when reacting with the acid of lemon, I think they just perfectly match. Be cautious using soda because it balances out the acid in your stomach. I always have it between or after meals.

5. Coconut oil. It's said that coconut oil contains lauric acid and caprylic acid which are potent at killing yeasts. I heard some people take it on a daily basis as a supplement for fighting yeast infection. I am not assured about its effect but there's no loose to give it a try. I use it as one of my cooking oil.

I have also been taking some other supplements but these are not related to yeasts - vitamin D which I'm deficient of, soy isoflavones for oestrogen deficiency, and fish oil to reduce inflammation and blood acidity.



So here comes the tricky part - you can't handle yeast and choline at the same time. Choline is rich in almost all the protein-rich food, and the anti-yeast diet mean to avoid carbohydrates. There's no way to reject both protein and carbohydrate at the same time. For this reason I simply eat whatever I want, despite sugar and refined carbohydrate food. I have small amounts of meat/fish from time to time for the reason that large amount of protein would damage you gut flora. I would suggest making yeast as a long-term managing target and avoid choline for short-term need.

There's a TMAU patient said that she's found herbal liver supplement helpful. I guess it was because this supplement enhanced liver functions, and therefore enhanced the capability of liver at metabolising TMA (by producing more FMO3?).

I once visited a lab doing genetic tests for TMAU1. The staff told me that there were parents who buy nano-fibre clothes for their TMAU child. Nano-fibre traps the smell molecules inside so the odour doesn’t spread out.


It's something beyond TMAU but somehow still relates to yeasts infections. I would be glad if you keep reading.

Going back to the time in mid 2012, I was doing my master degree project by investigating the topic of cancer stem cells. I worked on several cancer cell samples (collected from patients in the hospital) on daily basis. One day I accidentally stabbed on my thumb with a needle full of cancer cells. I quickly took off my glove and squeezed out blood from the wound, hoping the cancer cells would be flushed out together, which was an optimistic thought. I didn't mention it to my supervisor as I was struggling to get results from my experiments, didn't want to bring up anymore issue. When the disease struck me from mid 2013, I have had many times thought that whether this incident could be the real cause of my disease. However, I knew there were people suffering from the same symptoms as mine, and the cancer cell I worked on were soft-tissue tumours, which are rare. I always thought that if the cancer cells were to do anything to my body, it wouldn't be gastrointestinal problem and there should not be people having the same symptoms as I do.

It was until the beginning of this year (2016), I came across this scientific claim - cancer is actually a chronic infection of fungus/yeasts. Suddenly everything was linked - the yeast infection that I have battled throughout these years was actually the cancer cells I stabbed into my finger. It makes sense since yeasts have specific mechanism escaping from generating immune responses, they can survive in my body quietly after being injected without showing much signs and without being eliminated by the immune system. I have looked back at the time of experiment and there were some mild inflammation responses which I simply ignored and thought that I was just physically tired. I had always been a very healthy person who loved out door activities. It was a mystery to me how I could suddenly become so ill. My assumption is that these yeasts were from the incident and the food and environment in Taiwan was just a trigger by creating an opportunity for them to thrive.

I also remembered how the cancer cell samples we had in lab suddenly went on "yeast contamination" and I had to repeat my routine works in order to grow some more cells. If Dr Milton White, MD was able to find fungus spores in every tumour tissue sample he studied, whether the "yeast contaminations" of our samples were not a "contamination" but the growth on yeasts that were originally within the samples? There's also a scientific report saying that they found anti-fugal medicine having the capability of killing tumour cells. Now I think the "Cancer stem cell" which my supervisor has been chasing after were actually yeast but not a human stem cell or human tumour cell.

Thanks a lot if you are still reading it lol Opinions and discussions are very welcomed. In addition, I would like to ask a few more questions, in order to build up a shape of this illness. My aim isn't any longer to get myself cured, but I wish to find out the truth and therefore from now no one has to suffer from this lonely disease.

1. What's your diet style? Do you particularly love refined food, sweets, sugar-rich food?
2. Do you have any gastrointestinal symptoms, especially the ones similar to the leaky gut syndrome?
3. What's you gender? Do you have any female disorders such as hormone disorder, ovarian cysts, vaginal yeast infections, irregular menstrual cycles and etc?
4. Do you notice any other symptoms of yeast infections such as fatigue, muscle weakness, allergy and etc when the odour appeared?
5. Have you ever noticed that there might be a link between yeast infections and TMAU? Have you ever tried anything to handle yeasts? Was there any effect on improving the odour?
6. Have you ever had cancer?

I have come across this case with this guy curing his TMAU with anti-fungal medicine when I almost finished this article. ( ... my-result/) Now I am quite certain that TMAU is a yeast infection, and the position I would say ovary in women and to be investigated for men.
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Re: TMAU2 is a yeast infection of genital organ at the pelvi

Postby Lisa » Wed May 18, 2016 11:29 am

Do you mean Candida?
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