I just joined this forum a couple minutes ago as I was looking for some information on the treatment of TMAU. I've known about the possible connection between TMAU and heart disease for a while, but now that I found this forum, I thought I would post this. I can't say this is for sure, but I just wanted to post some potentially good news about TMAU, especially since all we ever hear is bad news (yeah, we stink, we get it, but otherwise our health is supposedly unaffected).
Well, I'm really interested in diet and health, and I've known for a long time that scientists have found a connection between heart disease and the odorless compound most peoples' bodies make from choline (the odorless compound is trimethylamine oxide or TMAO). Here is one article discussing the connection between TMAO and atherosclerosis, with more TMAO leading to more atherosclerosis. http://www.sciencenews.org/view/generic ... rt_disease
Here is an excerpt from the article:
"The researchers found 18 small molecules associated with fat buildup in the arteries. One of the best predictors turned out to be a by-product made when gut bacteria break down a fat called phosphatidylcholine (also known as lecithin).
"The more of this by-product, called trimethylamine N-oxide or TMAO, a person or mouse has in the blood, the higher the risk of getting heart disease, the researchers found.
"Gut bacteria are actually middlemen in TMAO production. The microbes convert lecithin to a gas that smells like rotten fish. Then an enzyme in the liver changes the foul-smelling gas to TMAO."
Anyway, as you all may know, our bodies do NOT produce this odorless compound from choline. Our bodies are unable to fully digest the choline into the odorless compounds.
My point is that I do think it's interesting that a compound our bodies can't produce (TMAO) is linked to heart disease.
Maybe that's why this genetic mutation has stuck around for so many years despite being such a stinky annoyance! Less heart disease means more opportunity to reproduce (as long as we don't put off our partners with our smell, hehe).
Anyway, just thought I'd share for some potentially good news about our condition.
Other people get heart disease from eating too much choline, and we may merely stink.